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Its application should be avoided in skin areas with dermatitis, open wounds, burns or infections, as well as covering the area with occlusive bandages, since a greater systemic absorption of diclofenac could be favored.
– Hypersensitivity to diclofenac or to any other component of the drug. There are reports of cross-allergic reactions between different NSAIDs, as well as with salicylates, so it is not recommended to use diclofenac in case of [NSAID ALLERGY] or [SALICYLATE ALLERGY].
– FDA Category C(D). Category C during the first 30 weeks of pregnancy and category D after the 30th week of pregnancy. Approximately 10% of the topical dose is absorbed systemically with considerably less bioavailability topically than orally. Adequate and well-controlled human studies with topical diclofenac are not available, but systemic diclofenac has resulted in fetal toxic effects in late pregnancy. Although skin absorption is minimal, systemic effects cannot be ruled out.

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Flogoprofen is a gel for dermal administration with 50 mg/mL of etofenamate, with great penetrating power and access to inflamed areas and synovial fluid, for the relief of painful processes involving inflammation such as diseases of the musculoskeletal system and adjacent structures, blows, sprains and strains, torticollis and lumbago, even with irradiation to the sciatic nerve.
The active ingredient of Flogoprofen is etofenamate at a concentration of 50 mg/mL. This acetic acid derivative is a phenamate (anthranilic acid) obtained from flufenamic acid, a non-steroidal anti-inflammatory. Its mechanism of action is based on the inhibition of cyclooxygenase in a competitive and non-irreversible manner, and inhibition of lipooxygenase and leukotrienes, unlike other current NSAIDs, which results in the suppression of the synthesis of eicosanoids such as prostaglandins and thromboxanes, reducing their sensitizing activity on sensitive endings and vasodilatation, as well as the chemical attraction of other substances to the site of the lesion involved in inflammatory processes.